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Vioxx is used to treat arthritis, acute pain, migraines, and menstrual pain and discomfort; this medicine is a nonsteroidal anti-inflammatory drug (NSAID) known as a COX-2 inhibitor used to relieve pain and swelling (inflammation). This drug works by blocking the enzyme in your body that makes prostaglandins. Vioxx can also be used in other circumstances for treatment, as if determined by your doctor.